Here from installed programs right-click on Microsoft Office.

Enter the Programs and Features section.

type control panel on the Start Menu screen and select it.Save your work and make sure all your Microsoft Office programs are closed.Your Microsoft Office might be corrupt, Repairing Office programs sometimes do the magic and fix Outlook not responding issue. In addition, you should avoid involving external content in your emails. Restart your PC and check if the issue has gone. Stop Outlook from Loading External Content Enable your add-ins one at a time to identify the culprit.Clear all the check boxes and then click on OK.select COM Add-ins and then check on Go button.Run Outlook in safe mode using “ outlook /safe”.When Outlook starts normally on safe mode, follow the steps below to Disable the outlook add-ins which may be causing outlook to stop working or not responding. fallow next step Take a look at your installed Outlook add-ins and disable them.If Outlook does not give you any problems, it is possible that one of its add-ins is creating problems.Now Press Windows + R, type outlook /safeand hit Enter.Here under the process tab look for Outlook.exe, Right-click and select End task.If you found yourself Out stuck at Not responding for a long time then open Task manager (Right-click on Taskbar or press Alt+ Ctrl+ Del and select task manager).If this is to no avail, contact your Security software manufacturer or opt for another solution. If it is, try to configure the software to allow Outlook on your PC. We advise you to turn off your antivirus product and see if the issue persists.

Temporarily disable your third-party antivirus software: Sometimes non-Microsoft security solutions might have come into conflict with Outlook and keeps it unresponsive. Note: Solutions are applicable to Microsoft Outlook 2007, 2010, 20 running Windows 10, 8.1 and 7 Computers.

Outlook crashes when opening profile